Willem de Wolf graduated in 1985 from the Amsterdam Theater School. In the same year he founded the theater duo Kas & de Wolf together with Ton Kas. Together, Kas & de Wolf wrote / made about 15 theater pieces. In 2002 they won the VSCD Mime Prize for their performance Ons soort mensen. Willem de Wolf wrote for, among others, Dood Paard and Mugmetdegoudentand. His text Krenz de gedoodverfde opvolger was nominated in 2012 for the Taalunie Toneelschrijfprijs. From 2004 to 2009 Willem de Wolf studied German Language & Culture at the University of Amsterdam. Since 2010 he is part of the artistic core of Compagnie de Koe.
Willem de Wolf is involved as a guest lecturer at the acting department of the Royal Conservatoire Antwerp.